Late cardiac, thyroid, and pulmonary sequelae of mantle radiotherapy for Hodgkin's disease

Journal Article · Fri Nov 01 04:00:00 EST 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90273-1· OSTI ID:6181339

Morgan, G W; Freeman, A P; McLean, R G; Jarvie, B H; Giles, R W

Cardiac, thyroid and pulmonary function were evaluated in 25 patients aged 35 years or under, treated for Hodgkin's disease by mantle radiotherapy 5-16 years previously. No patient had symptoms of heart disease. Although thallium myocardial perfusion scintigraphy was normal in all patients, abnormalities of myocardial function were detected in 6 (24%) patients using gated equilibrium rest and exercise radionuclide ventriculography. Resting left ventricular ejection fraction (LVEF) was abnormal in 1 patient, and in 3 patients there was an abnormal LVEF response to exercise. All 6 patients had right ventricular dilatation. Apical hypokinesia was present in 4 of these patients. A small asymptomatic pericardial effusion was detected by M-Mode echocardiography in only 2 (8%) patients. Twenty-three (92%) patients had evidence of abnormal thyroid function. Two (8%) patients had become clinically hypothyroid. Serum TSH was elevated in 13 (52%) patients and TRH stimulation test was abnormal in a further 10 (40%) patients in whom TSH was normal. Pulmonary function studies showed a moderate decrease in diffusing capacity (72% of predicted) and a minor reduction in lung volume. Although a high incidence of cardiac, thyroid and pulmonary abnormalities was detected, only the 2 patients who had become hypothyroid were symptomatic. Modification of the irradiation technique may reduce the incidence of cardiac abnormalities, but is unlikely to alter significantly the thyroid or pulmonary sequelae.

• Research Organization: Prince of Wales Hospital, Sydney, Australia
• OSTI ID: 6181339
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
COUNTING TECHNIQUES
DELAYED RADIATION EFFECTS
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DISEASES
DYNAMIC FUNCTION STUDIES
ELECTROCARDIOGRAMS
ELEMENTS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
EXERCISE
GLANDS
HEART
HODGKINS DISEASE
HORMONES
HYPOTHYROIDISM
LUNGS
LYMPHOMAS
MEDICINE
METALS
MUSCLES
MYOCARDIUM
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
PEPTIDE HORMONES
PERFUSED ORGANS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPE SCANNING
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SCINTISCANNING
SIDE EFFECTS
THALLIUM
THERAPY
THYROID
THYROID HORMONES
THYROXINE
TRIIODOTHYRONINE