Leukotrienes as mediators in tissue trauma

Journal Article · Fri Oct 18 04:00:00 EDT 1985 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.4048937· OSTI ID:6179602

Denzlinger, C; Rapp, S; Hagmann, W; Keppler, D

A significant increase in the production of cysteinyl leukotrienes was observed after mechanical or thermal trauma in the anesthesized rat. The amount of biliary N-acetyl-leukotriene E4, which represents a suitable indicator for blood plasma leukotrienes, was used as a measure of leukotriene generation. Cysteinyl leukotrienes were rapidly eliminated from blood plasma into bile where N-acetyl-leukotriene E4 was the major metabolite. Leukotrienes were at a much lower concentration in blood plasma than in bile and differed in the pattern of metabolites. The detected amounts of leukotrienes were sufficient to induce known phenomena associated with trauma, such as tissue edema and circulatory and respiratory dysfunction. Increased leukotriene generation appears to play an important role in the pathophysiology of tissue trauma.

• Research Organization: Universitaet Freiburg, West Germany
• OSTI ID: 6179602
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 4723; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BILE
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BODY FLUIDS
BURNS
EDEMA
FAILURES
FRACTURES
HALF-LIFE
INJURIES
KINETICS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
PATHOLOGICAL CHANGES
PHYSIOLOGY
RATS
RODENTS
SYMPTOMS
SYNTHESIS
TRITIUM COMPOUNDS
VERTEBRATES