Movement of fibroblasts in the periodontal ligament of the mouse incisor is related to eruption
Journal Article
·
· J. Dent. Res.; (United States)
Movement of fibroblasts in the periodontal ligament of the lower incisor of the mouse was studied by pulse-labeling with tritiated thymidine and proline. /sup 3/H-Thymidine was administered to mark the nuclei of the cells in the proliferative compartment near the basal end of the tooth; 3H-proline gave rise to a narrow band of radioactivity in the dentin, which served as a reference line for measurement of eruption. One or three weeks after injection in each animal, the lower right incisor was prevented from further eruption by being pinned to its alveolar process. The animals were killed 0, 1, or 2 weeks later, and their mandibles processed for LM-radioautography. It was found that in the left incisors, which were not inhibited in their eruption, labeled cells in the tooth-half of the periodontal ligament moved incisally at a rate similar to the eruption rate. In the pinned incisors, no further incisal migration could be established. It is concluded that fibroblast migration in the tooth-half of the ligament is strictly coupled to the eruptive process.
- Research Organization:
- Academic Center for Dentistry Amsterdam (ACTA), The Netherlands
- OSTI ID:
- 6178603
- Journal Information:
- J. Dent. Res.; (United States), Journal Name: J. Dent. Res.; (United States) Vol. 66:5; ISSN JDREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301 -- Cytology-- Tracer Techniques
550600* -- Medicine
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AMINO ACIDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
AZINES
AZOLES
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL DIVISION
CELL NUCLEI
CELL PROLIFERATION
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
DENTIN
DENTISTRY
DIGESTIVE SYSTEM
FIBROBLASTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
JAW
LABELLED COMPOUNDS
LIGAMENTS
MAMMALS
MEDICINE
MICE
NUCLEOSIDES
NUCLEOTIDES
ORAL CAVITY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROLINE
PYRIMIDINES
PYRROLES
PYRROLIDINES
RIBOSIDES
RODENTS
SKELETON
SKULL
SOMATIC CELLS
TEETH
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
VERTEBRATES
550600* -- Medicine
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AMINO ACIDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
AZINES
AZOLES
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL DIVISION
CELL NUCLEI
CELL PROLIFERATION
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
DENTIN
DENTISTRY
DIGESTIVE SYSTEM
FIBROBLASTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
JAW
LABELLED COMPOUNDS
LIGAMENTS
MAMMALS
MEDICINE
MICE
NUCLEOSIDES
NUCLEOTIDES
ORAL CAVITY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROLINE
PYRIMIDINES
PYRROLES
PYRROLIDINES
RIBOSIDES
RODENTS
SKELETON
SKULL
SOMATIC CELLS
TEETH
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
VERTEBRATES