Movement of fibroblasts in the periodontal ligament of the mouse incisor is related to eruption
Movement of fibroblasts in the periodontal ligament of the lower incisor of the mouse was studied by pulse-labeling with tritiated thymidine and proline. /sup 3/H-Thymidine was administered to mark the nuclei of the cells in the proliferative compartment near the basal end of the tooth; 3H-proline gave rise to a narrow band of radioactivity in the dentin, which served as a reference line for measurement of eruption. One or three weeks after injection in each animal, the lower right incisor was prevented from further eruption by being pinned to its alveolar process. The animals were killed 0, 1, or 2 weeks later, and their mandibles processed for LM-radioautography. It was found that in the left incisors, which were not inhibited in their eruption, labeled cells in the tooth-half of the periodontal ligament moved incisally at a rate similar to the eruption rate. In the pinned incisors, no further incisal migration could be established. It is concluded that fibroblast migration in the tooth-half of the ligament is strictly coupled to the eruptive process.
- Research Organization:
- Academic Center for Dentistry Amsterdam (ACTA), The Netherlands
- OSTI ID:
- 6178603
- Journal Information:
- J. Dent. Res.; (United States), Vol. 66:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
FIBROBLASTS
CELL PROLIFERATION
AUTORADIOGRAPHY
CELL DIVISION
CELL NUCLEI
DENTIN
DENTISTRY
JAW
LIGAMENTS
MICE
PROLINE
TEETH
THYMIDINE
TRITIUM COMPOUNDS
AMINES
AMINO ACIDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZINES
AZOLES
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORAL CAVITY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
PYRROLES
PYRROLIDINES
RIBOSIDES
RODENTS
SKELETON
SKULL
SOMATIC CELLS
TISSUES
VERTEBRATES
550600* - Medicine
550301 - Cytology- Tracer Techniques