Glucose utilization by intracranial meningiomas as an index of tumor aggressivity and probability of recurrence: a PET study

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.164.2.3496626· OSTI ID:6172408

Di Chiro, G; Hatazawa, J; Katz, D A; Rizzoli, H V; De Michele, D J

Seventeen patients with intracranial meningiomas were studied with positron emission tomography and fluorine-18-2-fluorodeoxyglucose (PET-FDG) to assess the glucose utilization of these tumors. Four meningiomas followed for 3-5 years after PET-FDG and surgery showed no evidence of recurrence. These tumors had significantly lower glucose utilization rates (1.9 mg/dl/min +/- 1.0) than 11 recurrent or regrowing meningiomas (4.5 mg/dl/min +/- 1.96). The glucose metabolic rates of meningiomas correlated with tumor growth, as estimated from changes in tumor size on repeated computed tomographic scans. Histopathologically, a syncytial (atypical) meningioma had the highest glucose utilization rate, followed by a papillary meningioma and an angioblastic meningioma. Individual transitional and syncytial (typical) meningiomas showed marked differences in glucose metabolism despite similar microscopic appearance. Glucose utilization rate appears to be at least as reliable as histologic classification and other proposed criteria for predicting the behavior and recurrence of intracranial meningiomas.

• Research Organization: National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD
• OSTI ID: 6172408
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 164:2; ISSN RADLA
• Country of Publication: United States
• Language: English

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