Dept. of Pharmacology and Toxicology, University of Rochester, School of Medicine and Dentistry, New York. [Effect of CdCl/sub 2/]

Journal Article · Fri Aug 01 00:00:00 EDT 1980 · Teratology; (United States)

OSTI ID:6170436

Levin, A A; Miller, R K

Fetal death in rats was produced by subcutaneous injections of CdC12 (40 mu moles/kg) on day 18 of pregnancy. The incidence of fetal death following these maternal injections was 74.9%, with mean (+/- SD) fetal cadmium burdens of 8.6 +/- 4.4 nmoles. To separate maternal from fetal effects of cadmium, doses of CdC12 up to 60 mu moles/kg fetal weight were injected directly into fetuses on day 18 of gestation. Fetal viability was then determined on gestational day 21. Following direct fetal injection, mean fetal body burdens of cadmium were 74.6 +/- 34.8 n moles, but the incidence of fetal dealth was only 11.5%. The high incidence of fetal death following maternal exposure to CdC12 is not solely explained by the direct effects of CdC12 on the fetus. Thus, the fetal toxicity of cadmium may be the result of some extra-fetal mechanism such as maternal toxicity or the observed placental necrosis.

• OSTI ID: 6170436
• Journal Information: Teratology; (United States), Vol. 22:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
TOXICITY
FETUSES
MORTALITY
BODY BURDEN
CADMIUM CHLORIDES
NECROSIS
PLACENTA
RATS
SUBCUTANEOUS INJECTION
VIABILITY
ANIMALS
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
ELEMENTS
FETAL MEMBRANES
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
MAMMALS
MEMBRANES
METALS
PATHOLOGICAL CHANGES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)