Cadmium fetotoxicity in rats following prenatal exposure
Timed pregnant Holtzman rats were received on day 3 of gestation, weighed, and housed in individual stainless steel cages. Tap water and food pellets were allowed ad libitum. The maternal weight gain was monitored throughout the gestationeal period. A single intraperitoneal injection of 1.0 or 2.0 mg/kg of cadmium, as cadmium acetate, was administered to pregnant rats on day 12, 14, 18, or 20 of gestation. Control rats received saline solution. Maternal rats receiving cadmium on day 12 or 14 of gestation (Groups I and II) were sacrificed 2 days later. The majority of maternal rats receiving cadmium on day 18 or 20 (Groups III and IV) were sacrificed on day 21 of gestation while a limited number of Group III and IV maternal animals were allowed parturition on day 21 of gestation and viable neonates sacrificed 2 days later and examined.
- Research Organization:
- Purdue Univ., West Lafayette, IN
- OSTI ID:
- 5209810
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 23:1/2; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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