Gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13)
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
A clone that cross-hybridizes with a mouse p53 probe has been isolated from a cDNA library of simian virus 40-transformed human fibroblasts. This cloned human p53 cDNA was used as a probe to examine DNAs obtained from human-rodent somatic cell hybrids that have segregated human chromosomes. The results show that the human p53 gene is located on chromosome 17. In addition, Southern analysis of hybrids prepared from human cells containing a chromosome 17 translocation allowed regional localization of the human p53 gene to the most distal band on the short arm of this chromosome (17p13). Localization of the p53 gene to 17p13 was confirmed by in situ hybridization of metaphase spreads with the human p53 probe.
- Research Organization:
- National Institutes of Health, Bethesda, MD
- OSTI ID:
- 6155626
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 83:1; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CLONING
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
DNA
DNA-CLONING
ELECTRON CAPTURE RADIOISOTOPES
FIBROBLASTS
GENES
GENETIC MAPPING
HYBRIDIZATION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOENZYMES
ISOTOPES
KARYOTYPE
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MAPPING
MICE
MICROORGANISMS
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
NUCLEOTIDES
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ONCOGENES
ORGANIC COMPOUNDS
PARASITES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOISOTOPES
RECOMBINANT DNA
RODENTS
SOMATIC CELLS
VERTEBRATES
VIRUSES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CLONING
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
DNA
DNA-CLONING
ELECTRON CAPTURE RADIOISOTOPES
FIBROBLASTS
GENES
GENETIC MAPPING
HYBRIDIZATION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOENZYMES
ISOTOPES
KARYOTYPE
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MAPPING
MICE
MICROORGANISMS
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
NUCLEOTIDES
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ONCOGENES
ORGANIC COMPOUNDS
PARASITES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOISOTOPES
RECOMBINANT DNA
RODENTS
SOMATIC CELLS
VERTEBRATES
VIRUSES