Presystemic branchial metabolism limits di-2-ethylhexyl phthalate accumulation in fish

Journal Article · Tue Mar 14 23:00:00 EST 1989 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(89)90133-6· OSTI ID:6154281

Barron, M G; Schultz, I R; Hayton, W L

Despite the high lipophilicity of di-2-ethylhexyl phthalate (DEHP), fish do not extensively accumulate this ubiquitous environmental contaminant. Experiments with rainbow trout (Salmo gairdneri) fitted with an indwelling cannula showed that the majority of (/sup 14/C)DEHP did not reach the systemic circulation of the fish, but was present in the exposure water as metabolites. Pharmacokinetic analysis, using a compartmental model that included the gill as a separate metabolic compartment, indicated that DEHP was extensively metabolized as it diffused from water to blood. Isolated perfused gill arches of trout metabolized DEHP in the exposure bath to monoethylhexyl phthalate, demonstrating the ability of the gill to prevent DEHP entry into the fish. The relationship between metabolic clearance and tissue perfusion further suggests that metabolism in the gill can play an important role in determining the accumulation and toxicity of organic chemical pollutants in fish.

• Research Organization: Washington State Univ., Pullman (USA)
• OSTI ID: 6154281
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 98:1; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MODELS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CLEARANCE
DICARBOXYLIC ACIDS
FISHES
GILLS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
METABOLISM
METABOLITES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PERFUSED TISSUES
PHTHALIC ACID
POLLUTION
RESPIRATORY SYSTEM
TISSUES
TRACER TECHNIQUES
TROUT
VERTEBRATES
WATER POLLUTION