Characterization of ROS1 cDNA from a human glioblastoma cell line

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.87.12.4799· OSTI ID:6151658

Birchmeier, C ^[1]; O'Neill, K; Riggs, M; Wigler, M ^[2]

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1. Max-Planck-Gesellschaft, Cologne (West Germany)
2. Cold Spring Harbor Laboratory, NY (USA)

The authors have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8.3 kilobases long, has the potential to encode a transmembrane tyrosine-specific protein kinase with a predicted molecular mass of 259 kDa. The putative extracellular domain of ROS1 is homologous to the extracellular domain of the sevenless gene product from Drosophila. No comparable similarities in the extracellular domains were found between ROS1 and other receptor-type tyrosine kinases. Together, ROS1 and sevenless gene products define a distinct subclass of transmember tyrosine kinases.

• OSTI ID: 6151658
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 87:12; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
RECOMBINANT DNA
DNA SEQUENCING
AMINO ACID SEQUENCE
GLIOMAS
MAN
ONCOGENES
PHOSPHOTRANSFERASES
PROTEINS
RECEPTORS
TUMOR CELLS
TYROSINE
AMINO ACIDS
ANIMAL CELLS
ANIMALS
CARBOXYLIC ACIDS
DISEASES
DNA
ENZYMES
GENES
HYDROXY ACIDS
MAMMALS
MEMBRANE PROTEINS
MOLECULAR STRUCTURE
NEOPLASMS
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PHOSPHORUS-GROUP TRANSFERASES
PRIMATES
STRUCTURAL CHEMICAL ANALYSIS
TRANSFERASES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques