Normal appearance and reproducibility of liver-spleen studies with /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid

Journal Article · Sat Jan 01 04:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:6148327

Klingensmith, W C; Spitzer, V M; Fritzberg, A R; Kuni, C C

In order to determine the normal biodistribution and reproducibility of /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid, each of ten normal subjects was studied twice with each of the two agents. In overexposed delayed analog images of the anterior chest, some thyroid radioactivity was demonstrated in all of 20 microalbumin colloid studies and in none of 20 sulfur colloid studies; lung radioactivity was seen in 19 of 20 (95%) sulfur colloid studies and in none of the microalbumin colloid studies (both p less than 0.001). Delayed digital images showed that the sulfur colloid gave a higher lung-to-heart ratio, a higher lung-to-liver ratio, and a lower bone marrow-to-liver ratio compared with microalbumin colloid (all p less than 0.05). In general, reproducibility was poor for both agents. We conclude that while there are some differences between these two radiocolloids, the differences do not indicate a superiority of the newer Tc-99m microalbumin colloid over the established Tc-99m sulfur colloid for liver-spleen imaging.

• Research Organization: University of Colorado Health Sciences Center, Denver
• OSTI ID: 6148327
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:1; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
BONE MARROW
COLLOIDS
COMPARATIVE EVALUATIONS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
ELEMENTS
GLANDS
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
IMAGES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MEDICINE
NONMETALS
NORTH AMERICA
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARTICLE SIZE
PROTEINS
RADIOCOLLOIDS
RADIOISOTOPES
RADIOLOGY
SIZE
SKELETON
SPLEEN
SULFUR
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIME DEPENDENCE
TISSUE DISTRIBUTION
TISSUES
USA
YEARS LIVING RADIOISOTOPES