Normal appearance and reproducibility of liver-spleen studies with /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid
In order to determine the normal biodistribution and reproducibility of /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid, each of ten normal subjects was studied twice with each of the two agents. In overexposed delayed analog images of the anterior chest, some thyroid radioactivity was demonstrated in all of 20 microalbumin colloid studies and in none of 20 sulfur colloid studies; lung radioactivity was seen in 19 of 20 (95%) sulfur colloid studies and in none of the microalbumin colloid studies (both p less than 0.001). Delayed digital images showed that the sulfur colloid gave a higher lung-to-heart ratio, a higher lung-to-liver ratio, and a lower bone marrow-to-liver ratio compared with microalbumin colloid (all p less than 0.05). In general, reproducibility was poor for both agents. We conclude that while there are some differences between these two radiocolloids, the differences do not indicate a superiority of the newer Tc-99m microalbumin colloid over the established Tc-99m sulfur colloid for liver-spleen imaging.
- Research Organization:
- University of Colorado Health Sciences Center, Denver
- OSTI ID:
- 6148327
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 24:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Biological mechanism of action of the potential myocardial perfusion imaging agent tr-(99m-Tc(DMPE)/sub 2/Cl/sub 2/)/sup +/
In vivo biodistribution of a radiolabeled blood substitute: sup 99m Tc-labeled liposome-encapsulated hemoglobin in an anesthetized rabbit
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
LIVER
BIOMEDICAL RADIOGRAPHY
RADIOCOLLOIDS
TISSUE DISTRIBUTION
SPLEEN
TECHNETIUM 99
ALBUMINS
BONE MARROW
COMPARATIVE EVALUATIONS
IMAGES
ISOMERIC NUCLEI
ISOTOPE APPLICATIONS
PARTICLE SIZE
SKELETON
SULFUR
TIME DEPENDENCE
USA
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COLLOIDS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
ELEMENTS
GLANDS
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NONMETALS
NORTH AMERICA
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RADIOLOGY
SIZE
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques