Tier II mutagenic screening of 13 NIOSH priority compounds. Individual compound report, 2-nitropropane

Technical Report · Wed Jul 01 04:00:00 EDT 1981

OSTI ID:6144344

McGregor, D B

2-Nitropropane (76469) (2NP) was subjected to a tier II mutagenic test screening program. The screening assays included unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours duration and concentrations up to 5000 micrograms per milliliter of culture medium; dominant lethal test in male rats with exposure to atmospheres containing 25 or 200 parts per million (ppm) 2NP for 7 hours per day for 5 days; sperm abnormality test in male mice using the same conditions; cytogenetic test in male and female rat bone marrow cells using the same exposure conditions; or a single exposure of 7 hours duration; and sex linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 700ppm for 4.5 hours. The author concludes that there was no evidence of genotoxic activity.

• Research Organization: Inveresk Research International Ltd., Musselburgh (UK)
• OSTI ID: 6144344
• Report Number(s): PB-83-152819
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARTHROPODS
BIOASSAY
BIOSYNTHESIS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DIPTERA
DNA
DROSOPHILA
FIBROBLASTS
FLIES
FRUIT FLIES
GAMETES
GERM CELLS
HAZARDOUS MATERIALS
INDUSTRIAL MEDICINE
INSECTS
INSPECTION
INVERTEBRATES
MAMMALS
MATERIALS
MEDICINE
MICE
MUTAGEN SCREENING
NATIONAL ORGANIZATIONS
NIOSH
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RODENTS
SCREENING
SOMATIC CELLS
SPERMATOZOA
SYNTHESIS
TOXICITY
US ORGANIZATIONS
VERTEBRATES