Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides

Journal Article · Wed Aug 01 00:00:00 EDT 1984 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(84)90102-6· OSTI ID:6133970

Lundborg, M; Camner, P

Groups of rabbits were exposed to chlorides of nickel, cadmium, copper, and cobalt at concentrations ranging from 0.2 to 0.6 mg/m/sup 3/ (as metal) for 4 to 6 weeks (5 days/weeks, 6 hr/day). Activity of lysozyme (muramidase) in lavage fluid, in alveolar macrophages, and in culture medium from macrophages incubated at 37/sup 0/C for 1 and 20 hr was estimated using the lyso-plate technique, agar plates with heat-killed Micrococcus lysodeikticus. In the nickel-exposed rabbits lysozyme activity in the mucous membrane from the left main bronchus was also estimated. Following nickel exposure the lysozyme level was significantly decreased in lavage fluid, macrophages, and in culture medium from incubated macrophages but remained unchanged in the mucous membrane. After exposure to cadmium, copper, and cobalt, lysozyme levels increased or were unchanged.

• Research Organization: Karolinska Inst., Stockholm, Sweden
• OSTI ID: 6133970
• Journal Information: Environ. Res.; (United States), Vol. 34:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM CHLORIDES
TOXICITY
COBALT CHLORIDES
COPPER CHLORIDES
LYSOZYME
ENZYME ACTIVITY
NICKEL CHLORIDES
BODY FLUIDS
BRONCHI
EXPERIMENTAL DATA
INHALATION
LUNGS
MACROPHAGES
MUCOUS MEMBRANES
RABBITS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BODY
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
COBALT COMPOUNDS
CONNECTIVE TISSUE CELLS
COPPER COMPOUNDS
COPPER HALIDES
DATA
ENZYMES
GLYCOSYL HYDROLASES
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
INFORMATION
INTAKE
MAMMALS
MATERIALS
MEMBRANES
NICKEL COMPOUNDS
NUMERICAL DATA
O-GLYCOSYL HYDROLASES
ORGANS
PHAGOCYTES
RESPIRATORY SYSTEM
SOMATIC CELLS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)