Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides

Journal Article · Wed Aug 01 04:00:00 EDT 1984 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(84)90102-6· OSTI ID:6133970

Lundborg, M; Camner, P

Groups of rabbits were exposed to chlorides of nickel, cadmium, copper, and cobalt at concentrations ranging from 0.2 to 0.6 mg/m/sup 3/ (as metal) for 4 to 6 weeks (5 days/weeks, 6 hr/day). Activity of lysozyme (muramidase) in lavage fluid, in alveolar macrophages, and in culture medium from macrophages incubated at 37/sup 0/C for 1 and 20 hr was estimated using the lyso-plate technique, agar plates with heat-killed Micrococcus lysodeikticus. In the nickel-exposed rabbits lysozyme activity in the mucous membrane from the left main bronchus was also estimated. Following nickel exposure the lysozyme level was significantly decreased in lavage fluid, macrophages, and in culture medium from incubated macrophages but remained unchanged in the mucous membrane. After exposure to cadmium, copper, and cobalt, lysozyme levels increased or were unchanged.

• Research Organization: Karolinska Inst., Stockholm, Sweden
• OSTI ID: 6133970
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 34:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BRONCHI
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
COBALT CHLORIDES
COBALT COMPOUNDS
CONNECTIVE TISSUE CELLS
COPPER CHLORIDES
COPPER COMPOUNDS
COPPER HALIDES
DATA
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
GLYCOSYL HYDROLASES
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
INFORMATION
INHALATION
INTAKE
LUNGS
LYSOZYME
MACROPHAGES
MAMMALS
MATERIALS
MEMBRANES
MUCOUS MEMBRANES
NICKEL CHLORIDES
NICKEL COMPOUNDS
NUMERICAL DATA
O-GLYCOSYL HYDROLASES
ORGANS
PHAGOCYTES
RABBITS
RESPIRATORY SYSTEM
SOMATIC CELLS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES