In vivo inactivation of lysozyme by ozone

Journal Article · Mon Jan 01 04:00:00 EST 1968 · J. Bacteriol.; (United States)

OSTI ID:6287223

Holzman, R S; Gardner, D E; Coffin, D L

Mice or rabbits were exposed to various doses of O/sub 3/ or NO/sub 2/. Lysozyme concentration in lung lavages decreased linearly with increasing O/sub 3/ dose (5 ppM x 3 hr reduced activity 30%) but returned to normal (linearly) within 12 hr post-exposure. Exposure increased pulmonary heterophils, decreased macrophages (no effect on peritoneal cell mixture which is principally heterophils), and decreased the rate of release of lysozyme from pulmonary and peritoneal cells. There was no effect of 30 ppM NO/sub 2/.

• OSTI ID: 6287223
• Journal Information: J. Bacteriol.; (United States), Journal Name: J. Bacteriol.; (United States) Vol. 96; ISSN JOBAA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CHALCOGENIDES
ENZYMES
GLYCOSYL HYDROLASES
HYDROLASES
INACTIVATION
LYSOZYME
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
OZONE
RABBITS
RODENTS
VERTEBRATES