Alterations in the lung following the administration of ozone

Journal Article · Fri Jan 01 04:00:00 EST 1971 · Arch. Intern. Med.; (United States)

DOI:https://doi.org/10.1001/archinte.128.1.81· OSTI ID:6227278

Huber, G L; Mason, R J; LaForce, M; Spencer, N J; Gardner, D E; Coffin, D L

Rabbits were exposed to 5 ppM O/sub 3/ for 3 hr. An increase in heterophils (from 2 to 3% to 34 to 50%) and ciliated epithelium cells (from 2 to 3% to 8 to 16%) in lung lavage was noted. Control lavage contained almost pure alveolar macrophages. RBC were also present in O/sub 3/-exposed animal lavages. Essentially all macrophages and ciliated epithelial cells in O/sub 3/ group were damaged or dead. No significant changes were found in surface tension properties including lecithin composition. There were no significant morphological differences apart from increase in cell debris in alveoli.

• OSTI ID: 6227278
• Journal Information: Arch. Intern. Med.; (United States), Journal Name: Arch. Intern. Med.; (United States) Vol. 128; ISSN AIMDA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
EPITHELIUM
ERYTHROCYTES
ESTERS
INHALATION
INTAKE
LAVAGE
LECITHINS
LIPIDS
LUNGS
MACROPHAGES
MAMMALS
MORPHOLOGY
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OZONE
PATHOLOGICAL CHANGES
PHAGOCYTES
PHOSPHOLIPIDS
POLLUTION
RABBITS
RESPIRATORY SYSTEM
SOMATIC CELLS
SURFACE PROPERTIES
SURFACE TENSION
TISSUES
TOXICITY
VERTEBRATES