Fibronectin concentrations in lung lavage fluid after inhalation exposure to low levels of metals

Journal Article · Mon Jun 01 04:00:00 EDT 1987 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(87)80069-5· OSTI ID:5764704

Berghem, L; Hansson, M; Lundborg, M; Camner, P

Groups of rabbits were exposed by inhalation to chlorides of cobalt, nickel, and manganese as well as to tri- and hexavalent chromium at metal concentrations ranging from 0.4 to 3.9 mg/m/sup 3/ for 1-4 months (5 days/week, 6 hr/day). Fibronectin content and lysozyme (muramidase) activity in lavage fluid were measured after all treatments and in alveolar macrophages after treatment with nickel chloride. In the lavage fluid no marked changes were seen in fibronectin content and lysozyme activity after exposure to tri- or hexavalent chromium or manganese. Nickel exposure significant decreased the lysozyme activity in the lavage fluid and in the macrophages whereas the fibronectin content was unchanged in the lavage fluid and significantly increased in the macrophages. Both fibronectin content and lysozyme activity were increased markedly in the lavage fluid after cobalt exposure.

• Research Organization: National Defense Research Institute, Umea, Sweden
• OSTI ID: 5764704
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 43:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOHYDRATES
CHLORIDES
CHLORINE COMPOUNDS
COBALT COMPOUNDS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
ENZYME ACTIVITY
ENZYMES
GLUCOPROTEINS
GLYCOSYL HYDROLASES
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
INHALATION
INTAKE
KINETICS
LAVAGE
LUNGS
LYSOZYME
MACROPHAGES
MAMMALS
MANGANESE COMPOUNDS
MATERIALS
NICKEL COMPOUNDS
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
PROTEINS
RABBITS
REACTION KINETICS
RESPIRATORY SYSTEM
SACCHARIDES
SOMATIC CELLS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES