Rabbit lung after inhalation of soluble nickel. I. Effects on alveolar macrophages

Journal Article · Tue Feb 01 04:00:00 EST 1983 · Environ. Res.; (United States)

OSTI ID:5706232

Wiernik, A ^[1]; Johansson, A; Jarstrand, C; Camner, P

---

1. Roslagstulls Hospital, Stockholm, Sweden

Alveolar macrophages from eight rabbits, exposed for about 1 month (5 days/week, 6 hr/day) to an aerosol of nickel chloride, 0.3 mg/m/sup 3/ (as Ni), were studied. The number of macrophages in the lavage fluid and the variance of the cell diameter increased. The macrophages contained laminated structures and most cells had an active cell surface. A few macrophages had a large number of laminated structures and a smooth cell surface. The capacity of the macrophages to reduce nitroblue tetrazolium (NBT) tended to be increased at rest and was significantly increased after stimulation with Escherichia coli. The bactericidal capacity of the macrophages was decreased. The effects were similar to those earlier described after exposure of rabbits for 1 month to about 1 mg/m/sup 3/ of metallic nickel dust. After exposure both to metallic and soluble nickel the effects are probably caused by an increased amount of surfactant produced by the type II cells in response to nickel ions.

• OSTI ID: 5706232
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 30:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
DUSTS
HALIDES
HALOGEN COMPOUNDS
INJURIES
LUNGS
MACROPHAGES
MAMMALS
NICKEL CHLORIDES
NICKEL COMPOUNDS
ORGANS
PHAGOCYTES
PRODUCTION
RABBITS
RESPIRATORY SYSTEM
SENSITIVITY
SOLS
SOLUBILITY
SOMATIC CELLS
SURFACTANTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES