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Influence of dietary selenium on mouse lung biochemical response and tolerance to ozone inhalation

Thesis/Dissertation ·
OSTI ID:6133545
This study examined whether altered selenium (Se) intake with or without ozone (O/sub 3/) stress would result in a possible 1) dose-response relationship between lung Se and glutathione peroxidase, 2) influence of Se on other lung parameters, 3) interrelationship between lung Se and vitamin E contents, and 4) alteration of lung sensitivity or tolerance to O/sub 3/. The results showed the following: 1) Omission of dietary Se resulted in a drastic decline in GP activity but did not affect the other enzyme activities studied. 2) A stimulation of the PPC and CAC activites with low-level O/sub 3/ exposure occurred only in Se-supplemented mice. The stimulation was greater in the lungs of mice fed 1.0 ppm Se compared to 0.15 ppm, i.e., the response was Se-dose dependent in this range. 3) Diminished GP activity possibly resulted in a decreased demand for NADPH produced via not only the PPC but also the CAC. 4) An inverse relationship was observed between Se and vitamin E contents in lung tissue, showing that a compensatory relationship existed between the two. 5) After each O/sub 3/ exposure Se content increased in lung tissue of both dietary groups, suggesting a possible mobilization of Se to the lung under O/sub 3/ stress. 6) Decreased GP activity due to Se deficiency and the ensuring lack of stimulated NADPH production in the lung did not alter the animal sensitivity to O/sub 3/, suggesting that GP reaction and NADPH production cycles were not crucial for animal tolerance.
OSTI ID:
6133545
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHEMISTRY
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INGESTION
INTAKE
LUNGS
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OZONE
PEROXIDASES
PORPHYRINS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
SELENIUM
SEMIMETALS
TOLERANCE
VERTEBRATES
VITAMIN E
VITAMINS