Calcium regulation and physiological function in animals exposed to lead

Book · Tue Jan 01 04:00:00 EST 1974

OSTI ID:6133261

Hoffman, N E

Tissue distribution studies of calcium and lead in brain tissue of rats were increased subsequent to a single intravenous injection of lead, 10 mg/kg, in the form of lead acetate. Time-course studies demonstrated that brain concentrations of calcium and lead (in terms of wet tissue weight) were found to be increased at days 1, 3 and 7 post treatment. At 24 hours brain levels of calcium and lead were elevated 70 and 350%, respectively. Over the subsequent 48 hours, brain levels of calcium reached maximal values and brain lead decreased slightly from day 1 values. At the end of 7 days, brain concentrations of calcium and lead were still elevated significantly above controls. The effect of lead on calcium in liver, heart, kidneys, skeletal muscles, smooth muscles, hair, bone and serum of lead-exposed rats were not significantly altered. Studies were undertaken to determine if the effect was mediated by the thyroid-parathyroid complex. Calcium concentrations in the brain of lead-treated thyroparathyroidectomized rats were 30, 47 and 70% lower at days 1, 3 and 7, respectively, when compared to levels of intact lead-injected rats at 10 mg/kg. Brain levels of lead in lead-treated rats were comparable to levels in treated intact animals. This implies that the thyroparathyroid system was necessary for complete expression of increased levels of brain calcium, but not essential for lead distribution in brain tissue of rats.

• OSTI ID: 6133261
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CALCIUM
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ENDOCRINE GLANDS
GLANDS
HEART
INJECTION
INTAKE
INTRAVENOUS INJECTION
KIDNEYS
LEAD
LIVER
MAMMALS
METALS
MUSCLES
ORGANS
PARATHYROID GLANDS
RATS
RODENTS
THYROID
TISSUE DISTRIBUTION
VERTEBRATES