Lead distribution in rats repeatedly treated with low doses of lead acetate

Journal Article · Sat Apr 01 04:00:00 EST 1989 · Environmental Research; (USA)

DOI:https://doi.org/10.1016/S0013-9351(89)80037-4· OSTI ID:7194172

P'an, A Y.S.; Kennedy, C ^[1]

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1. Univ. de Montreal, Quebec (Canada)

Male Sprague-Dawley rats were treated with ip injections of lead acetate (10 and 20 mg/kg) at intervals 1, 2, 4, 8, 12, 16, 20, and 24 weeks. Eight rats from each specified injection group were sacrificed 48 hr after the end of each treatment. Lead was determined in whole blood, plasma, plasma filtrate, saliva, urine, feces, brain, salivary glands, liver, kidney, testes, femur, and fur. In the liver, the concentrations of lead fluctuated; in the salivary glands and testes, lead levels were low. In the bone, the kidney, and the brain, lead accumulated steadily and reached high levels in bone and renal tissues, but remained low in the brain. Correlation analysis showed a reciprocal relationship between blood-lead and kidney-lead in the rats treated with 10 mg lead acetate/kg. In the rats treated with 20 mg lead acetate/kg, urine-lead was correlated to kidney-lead. In both groups of treated rats, fur-lead was correlated to kidney-lead.

• OSTI ID: 7194172
• Journal Information: Environmental Research; (USA), Journal Name: Environmental Research; (USA) Vol. 48:2; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CORRELATIONS
DIGESTIVE SYSTEM
DISTRIBUTION
FECES
GLANDS
GONADS
HAIR
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KIDNEYS
LEAD COMPOUNDS
LIVER
MALE GENITALS
MAMMALS
MATERIALS
ORGANS
RATS
RODENTS
SALIVARY GLANDS
SKELETON
SKIN
TESTES
TISSUE DISTRIBUTION
URINE
VERTEBRATES
WASTES