Excretion and retention of Se/sup 75/ in relation to modes of administration, toxicity, and pregnancy in rats

Conference · Wed Jan 01 04:00:00 EST 1964 · Wyo Agric Exp Stn Bull; (United States)

OSTI ID:6133228

Rosenfeld, I

Selenium excretion and retention in tissues were studied in groups of rats by the use of tracer amounts (7.5 ..mu..g Se) of selenite-Se/sup 75/. Data on elimination of selenium indicate that total elimination following repeated administrations (by various routes) does not differ significantly, but the amount excreted by the kidney, gut, and lung shows some differences. The main mode of elimination with atoxic (tracer) doses of selenium is the urinary tract, since over 40% of the injected dose is excreted by the gastrointestinal tract and lung. Selenium was eliminated by the urinary, gastrointestinal, and respiratory tracts up to 150 days. Respiratory elimination ceased after three days after subcutaneous injections. Administration of repeated subacute toxic doses (2.5 Se mg/kg) increased selenium retention in the blood and kidney. Repeated subacuate toxic doses of selenium reversed the route of elimination as indicated by the decreased rate of urinary excretion and increased excretion of Se/sup 75/ in the feces and by the lung. Se/sup 75/ retained by the tissues is metabolically active. Pregnancy increased the elimination of selenium by the respiratory tract in both groups, but this increase was higher in the group that received subacute toxic doses. Subacute toxic doses of selenium increased the Se/sup 75/ content of the red blood cells, placenta, and aminiotic fluid, but fetuses contained slightly less Se/sup 75/ than the group that received the tracer doses. 17 references, 5 figures, 4 tables.

• Research Organization: Univ. of California Medical School, San Francisco
• OSTI ID: 6133228
• Conference Information: Journal Name: Wyo Agric Exp Stn Bull; (United States) Journal Volume: 414
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
553001 -- Agriculture & Food Technology-- Tracer Techniques-- (-1987)
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
EXCRETION
FECES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MATERIALS
METABOLISM
NUCLEI
RADIOISOTOPES
RATS
RETENTION
RODENTS
SELENIUM
SELENIUM 75
SELENIUM ISOTOPES
SEMIMETALS
TISSUE DISTRIBUTION
TOXICITY
URINE
VERTEBRATES
WASTES