EXCRETION AND RETENTION OF Se$sup 75$ IN RELATION TO MODES OF ADMINISTRATION, TOXICITY, AND PREGNANCY. Final Report

Technical Report · Mon Jan 01 04:00:00 EST 1962

OSTI ID:4786412

Rosenfeld, I

Selenium retention in tissues and excretions were studied in rats by the use of tracer amounts (7.5 mu g Se) of selenite -Se/sup 75/. The selenium was given intraperitoneally, intragastrically, and subcutaneously. Data on the elimination of selenium by urinary, gastrointestinal,and respiratory tracts are given. The administration of repeated chronic toxic doses (2.5 Se mg/kg) increased the selenium retention in the blood and kidney, and large amounts of Se/ sup 75/ were present in the intestinal tract. Functional damage to the kidney and gastrointestinal tract was produced in chronic selenosis. The biological half life of Se/sup 75/ in the tracer (atoxic) group was 0--24 hours, and in the toxic group was 48 or 72 hours. Data on tissue retention and excretion of Se/sup 75/ in urine, feces, and respiratory tract in chronic selenosis are presented along with placental transmission of Se/sup 75/ and distribution of retained Se/ sup 75/ in the fetuses and maternal tissues subsequent to repeated administration of chronic toxic and tracer doses of selenium. The retained selenium is metabolically active and released slowly from tissues. (auth)

• Research Organization: Wyoming. Univ., Laramie
• NSA Number: NSA-16-030198
• OSTI ID: 4786412
• Report Number(s): TID-16577
• Country of Publication: United States
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
FECES
FETUSES
HALF-LIFE
INTESTINE
KIDNEYS
LUNGS
METABOLISM
PREGNANCY
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RATS
SELENIUM 75
TOXICITY
TRACER TECHNIQUES
URINE