Cytogenetic investigations of human subjects occupationally exposed to chemicals from the petroleum-processing industry
Journal Article
·
· Environ. Res.; (United States)
A cytogenetic investigation was carried out of 55 workers from the petroleum-processing industry and of 30 control subjects. The frequencies of both structural and numerical chromosome aberrations and of sister chromatid exchanges were determined simultaneously and the relationship among these cytogenic indices were analyzed. The incidence of chromosome aberrations and sister chromatid exchanges among the petroleum workers was higher than that among the controls. The cytogenic indices demonstrated a clear dependence on the working environment of the subjects and a correlation with the existence of some reproductive failures in the families of the exposed workers. Our results indicate the presence of some mutagenic risk in the working environment of some of the divisions in the petroleum-processing industry due to the genotoxic influence on the somatic cells of the exposed workers at a cytogenetic level. This potential risk is mainly associated with the presence of some heavy oil-fractions and polycyclic aromatic hydrocarbons in the working environment.
- Research Organization:
- Univ. School of Medicine, Pleven (Bulgaria)
- OSTI ID:
- 6120727
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 48:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
02 PETROLEUM
020600* -- Petroleum-- Health & Safety
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BULGARIA
CELL CULTURES
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DEVELOPING COUNTRIES
EASTERN EUROPE
ENERGY SOURCES
ENVIRONMENTAL EXPOSURE
EUROPE
FOSSIL FUELS
FUELS
GENETIC EFFECTS
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
INDUSTRY
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTAGENESIS
MUTATIONS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
PERSONNEL
PETROLEUM
PETROLEUM INDUSTRY
POLYCYCLIC AROMATIC HYDROCARBONS
REPRODUCTION
RISK ASSESSMENT
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TOXICITY
020600* -- Petroleum-- Health & Safety
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BULGARIA
CELL CULTURES
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DEVELOPING COUNTRIES
EASTERN EUROPE
ENERGY SOURCES
ENVIRONMENTAL EXPOSURE
EUROPE
FOSSIL FUELS
FUELS
GENETIC EFFECTS
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
INDUSTRY
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTAGENESIS
MUTATIONS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
PERSONNEL
PETROLEUM
PETROLEUM INDUSTRY
POLYCYCLIC AROMATIC HYDROCARBONS
REPRODUCTION
RISK ASSESSMENT
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TOXICITY