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Metabolism of methyl mercury (/sup 203/Hg) compounds in man: excretion and distribution

Journal Article · · Arch. Environ. Health; (United States)
; ; ;
The oral intake of 2.6..mu..Cl of methyl-mercuric nitrate Hg 203 by three clinically healthy, white, male volunteers aged 37 to 44 years resulted in an accumulation in the liver and the head of the /sup 203/Hg. The main excretory route was the feces but the urinary excretion increased with time up to 30 days after the intake. The biological half-life was found with whole body measurements to be 70 to 74 dyas. The decline of /sup 203/Hg in the head was less rapid than in the rest of the body. No /sup 203/Hg was found in the sperm. A very rapid uptake was found in the erythrocytes. The main activity was localized in the liver (about 50% of the contents of the body) whereas the head contained about 10% of the total body content. After infinite time a weekly unit dose of methyl mercuric nitrate Hg 203 will result in a whole body burden of 15.2 units mercury. 19 references, 6 figures, 2 tables.
Research Organization:
Royal Veterinary Coll., Stockholm, Sweden
OSTI ID:
6108732
Journal Information:
Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 19; ISSN AEHLA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ERYTHROCYTES
EVEN-ODD NUCLEI
EXCRETION
GLANDS
HEAD
HEAVY NUCLEI
ISOTOPES
LIVER
MAMMALS
MAN
MATERIALS
MERCURY 203
MERCURY COMPOUNDS
MERCURY ISOTOPES
METABOLISM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES