Mutagenicity, sister chromatid exchange inducibility and in vitro cell transforming ability of particulates from Athens air

Journal Article · Tue Sep 01 04:00:00 EDT 1987 · Cell Biol. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF00117863· OSTI ID:6103588

Athanasiou, K; Arzimanoglou, I; Piccoli, C; Yamasaki, H

Airborne particulates were collected over a period of twelve months by the use of Hi-Vol samplers in the basin of Athens, Greece. N-Hexane extracts were tested in a battery of in vitro tests for their ability to induce mutation in bacteria as well as mutations, sister chromatid exchange and morphological transformation in cultured mammalian cells. Positive results were found for mutagenicity with Salmonella strain TA98 in the Ames assay, for sister chromatid exchange induction in CHO cells and for transformation in BALB/c 3T3 cells in culture. They also showed weak non-dose-related induction of ouabain resistance in BALB/c 3T3 cells. The contribution of oxidizing and nitrating agents found in the Athens atmosphere, together with sunlight UV irradiation in the formation of direct acting mutagens and potential carcinogens from ambient polycyclic aromatic hydrocarbons, is suggested.

• Research Organization: National Hellenic Research Foundation, Athens (Greece)
• OSTI ID: 6103588
• Journal Information: Cell Biol. Toxicol.; (United States), Journal Name: Cell Biol. Toxicol.; (United States) Vol. 3:3; ISSN CBTOE
• Country of Publication: United States
• Language: English

Related Subjects

500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AIR SAMPLERS
ALKANES
ANIMAL CELLS
ANIMALS
AROMATICS
BACTERIA
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DEVELOPING COUNTRIES
DRUGS
EASTERN EUROPE
EQUIPMENT
EUROPE
FIBROBLASTS
GLYCOSIDES
GREECE
HAMSTERS
HEXANE
HYDROCARBONS
IN VITRO
MAMMALS
MICE
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENS
MUTATIONS
NITRATES
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
OUABAIN
OXYGEN COMPOUNDS
PHOTOCHEMICAL OXIDANTS
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SAMPLERS
SAMPLING
SCREENING
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
STROPHANTHINS
VERTEBRATES