Cell cycle traverse in NHIK-3025 carcinoma of the uterine cervix after low-dose-rate irradiation
Journal Article
·
· Radiat. Res.; (United States)
Theoretically, fractionation schemes could be tailored to the individual pattern of radiation-induced synchronization of cells in the radiosensitive G2 phase, leading to more effective radiotherapy. Using a human cervical carcinoma xenografted to nude mice, the effects of low-dose-rate irradiation on the cell cycle distribution were studied. Flow cytometric analysis demonstrated that cells accumulated in G2 + M phase 35 h after a total dose of 10 Gy of /sup 137/Cs irradiation. This accumulation time corresponded closely to the cell cycle time (Tc) (31 h) of this tumor, as determined by autoradiography. Further experiments are planned to determine the potential of fractionation schemes adjusted to the Tc-related accumulation in G2 in improving the effectiveness of radiotherapy.
- Research Organization:
- University Hospital Utrecht (Netherlands)
- OSTI ID:
- 6098776
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 118:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
ON THE PROBLEM OF HISTOCHEMICAL TESTING OF RADIOSENSITIVITY OF CARCINOMA OF THE UTERINE CERVIX
Effect of X irradiation on a heterotransplanted human colonic carcinoma before and after a change in the cellular DNA content
Effect of X irradiation on a heterotransplanted human colonic carcinoma before and after a change in the cellular DNA content
Journal Article
·
Sat Dec 31 23:00:00 EST 1960
· Neoplasma (Czechoslovakia)
·
OSTI ID:4739207
Effect of X irradiation on a heterotransplanted human colonic carcinoma before and after a change in the cellular DNA content
Journal Article
·
Mon Jan 31 23:00:00 EST 1983
· Radiat. Res.; (United States)
·
OSTI ID:5849216
Effect of X irradiation on a heterotransplanted human colonic carcinoma before and after a change in the cellular DNA content
Journal Article
·
Mon Jan 31 23:00:00 EST 1983
· Radiat. Res.; (United States)
·
OSTI ID:6253427
Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
CELL CYCLE
CELL FLOW SYSTEMS
CESIUM 137
CESIUM ISOTOPES
DISEASES
FEMALE GENITALS
FRACTIONATED IRRADIATION
IRRADIATION
ISOTOPES
LOW DOSE IRRADIATION
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
UTERUS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
CELL CYCLE
CELL FLOW SYSTEMS
CESIUM 137
CESIUM ISOTOPES
DISEASES
FEMALE GENITALS
FRACTIONATED IRRADIATION
IRRADIATION
ISOTOPES
LOW DOSE IRRADIATION
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
UTERUS
VERTEBRATES
YEARS LIVING RADIOISOTOPES