ON THE PROBLEM OF HISTOCHEMICAL TESTING OF RADIOSENSITIVITY OF CARCINOMA OF THE UTERINE CERVIX
Cytochemical tests were used in attempts to correlate the results with the radiosensitivity of 45 cervical carcinomas of the epidermoid type. Periodic acid-Schiff staining and alkaline phosphatase activity of the tumor both increased after treatment (radium and x radiation) but the changes were similar in radiosensitive and radioresistant tumors. DNA content, as seen by Feulgen stained preparations, declined to a greater degree in radiosensitive than resistant tumors. The greatest degree of correlation with radiosensitivity was found with RNA in methyl greenpyronine-orange G stained sections. RNA content increased in radiosensitive cells and decreased in cells that later proved resistant to radiotherapy. It is emphasized that radiosensitivity is not synonomous with radiocurability of a tumor. In some instances, apparently, radiosensitive tumors disappeared but recurred as radioincurable lesions, whereas, in other cases, cancer cells persisted after radiotherapy as seen by cytologic examination but the tumors did not recur. (H.H.D.)
- Research Organization:
- Oncological Research Inst., Bratislava
- NSA Number:
- NSA-17-017686
- OSTI ID:
- 4739207
- Journal Information:
- Neoplasma (Czechoslovakia), Journal Name: Neoplasma (Czechoslovakia) Vol. Vol: 8; ISSN NEOLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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