CONSIDERATIONS ON THE RADIOSENSITIVITY OF CERVICAL UTERINE CANCERS. I. STUDY OF THE CRITERIA OF RADIOSENSITIVITY OF CERVICAL UTERINE CANCERS

Journal Article · Sat Sep 01 04:00:00 EDT 1962 · Pathol. Biol. Semaine Hop.

OSTI ID:4754198

Darcis, L

Radiosensitivity of tumors is considered from the point of view of the tumor itseif and of the host tissue. Characteristics of tumors are discussed in relation to their macroscopic and histologic appearamce, cytology as seen in vaginal smears, histo- and cytochemistry, uptake of radioisotopes, and possibilities of culture in vitro. Macroscopically, exophytic tumors are considered more amenable to radiotherapy than endophytic types. They tend to be discovered earlier, are less invasive, and their better vascularization makes them more radiosensitive. The early response of exophytic tumors to irradiation has longterm prognostic significance. With 272 irradiated exophytic cervicai carcinomas the 5-yr survivai rate was 71% after an initial favorable reaction compared with only 23% after a poor initial radioresponse. Histologically, there is some evidence that the more differentiated tumors are more radioresponsive. Biopsy of irradiated tumors may indicate their radiosensitivity, e.g., the presence of cells in telophase and normal anaphase may be interpreted as a sign of radioresistance. Rapid dinappearance of cancer cells in vaginal smears after irradiation is of favorable prognostic significance. The failure of irradiated tumor cells to show a fall in deoxyribonucleic acid content indicates radioresistance; this may also be interpreted from the rate of P/sup 32/ uptake of the cells before and after irradiation. Reactions of normal host cells to irradiation are also of prognostic value. Marked cytologic changes in normal cells and appearance of inflammatory cells in vaginal smears indicate a good response, whereas cornification reflects radioresistance. However, no singie factor, but a combination of factors, must be considered in assessing the radiosensitivity of cervical carcinomas. (H.H.D.)

• Research Organization: Universite, Liege
• NSA Number: NSA-17-005869
• OSTI ID: 4754198
• Journal Information: Pathol. Biol. Semaine Hop., Journal Name: Pathol. Biol. Semaine Hop. Vol. Vol: 10
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOCHEMISTRY
BIOLOGY AND MEDICINE
CANCER
CYTOLOGY
LIFETIME
MAN
MEDICINE
MICROSCOPY
MITOSIS
NUCLEIC ACIDS
PHOSPHORUS 32
QUANTITY RATIO
RADIOSENSITIVITY
RADIOTHERAPY
SEX
TRACER TECHNIQUES