Relationship between repair processes and mutation induction in bacteria. [UV radiation; methyl methanesulfonate; N-methyl-N/sup 1/-nitro-N-nitrosoguanidine; N-methyl-N-nitrosourea; N-ethyl-N-nitrosourea; ethyl methanesulfanate; N-ethyl-nitrosoguanidine; 4-nitroquinoline 1-oxide]
Conference
·
OSTI ID:6098705
The main repair and replication-associated processes that can influence the induction of mutations by various mutagens in bacteria are reviewed. These include both constitutive and induced, error-free and error-prone systems. The mutation yield from a treatment with a mutagen can be markedly affected by which of these systems is operating in a given bacterial species or strain. The effect of these systems on mutation induction by ultraviolet light, monofunctional alkylating agents, base analogues, and frameshift mutagens is discussed in some detail. The bearing of these studies on the practical problems of estimating hazards is briefly considered. 79 references.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6098705
- Report Number(s):
- CONF-790676-1
- Resource Relation:
- Conference: Conference on DNA repair and mutagenesis in bacteria, Atlanta, GA, USA, 25 Jun 1979
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
BACTERIA
MUTAGENESIS
BIOLOGICAL MODELS
MUTAGENS
MUTATIONS
BIOLOGICAL REPAIR
ULTRAVIOLET RADIATION
ALKYLATING AGENTS
BIOLOGICAL EFFECTS
DNA REPLICATION
ESCHERICHIA COLI
HEALTH HAZARDS
METHYL METHANESULFONATE
MUTAGEN SCREENING
PROTEUS
RISK ASSESSMENT
SALMONELLA
ANTIMITOTIC DRUGS
BIOLOGICAL RECOVERY
DRUGS
ELECTROMAGNETIC RADIATION
ESTERS
HAZARDS
MICROORGANISMS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATIONS
RECOVERY
REPAIR
SCREENING
SULFONIC ACID ESTERS
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)
560400 - Other Environmental Pollutant Effects
550400 - Genetics
59 BASIC BIOLOGICAL SCIENCES
BACTERIA
MUTAGENESIS
BIOLOGICAL MODELS
MUTAGENS
MUTATIONS
BIOLOGICAL REPAIR
ULTRAVIOLET RADIATION
ALKYLATING AGENTS
BIOLOGICAL EFFECTS
DNA REPLICATION
ESCHERICHIA COLI
HEALTH HAZARDS
METHYL METHANESULFONATE
MUTAGEN SCREENING
PROTEUS
RISK ASSESSMENT
SALMONELLA
ANTIMITOTIC DRUGS
BIOLOGICAL RECOVERY
DRUGS
ELECTROMAGNETIC RADIATION
ESTERS
HAZARDS
MICROORGANISMS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATIONS
RECOVERY
REPAIR
SCREENING
SULFONIC ACID ESTERS
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)
560400 - Other Environmental Pollutant Effects
550400 - Genetics