Relationship between repair processes and mutation induction in bacteria

Journal Article · Tue Jan 01 00:00:00 EST 1980 · Basic Life Sci.; (United States)

DOI:https://doi.org/10.1007/978-1-4684-3842-0_1· OSTI ID:6029282

Kimball, R F

A summary is given of the main repair and replication-associated processes that can influence the induction of mutations by various mutagens in bacteria. These include both constitutive and induced, error-free and error-prone systems. The mutation yield from a treatment with a mutagen can be markedly affected by which of these systems is operating in a given bacterial species or strain. The effect of these systems on mutation induction by ultraviolet light, monofunctional alkylating agents, base analogues, and frameshift mutagens is discussed in some detail. The bearing of these studies on the practical problems of estimating hazards is briefly considered.

• OSTI ID: 6029282
• Journal Information: Basic Life Sci.; (United States), Vol. 15
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DNA
BIOLOGICAL REPAIR
MUTAGENS
GENETIC EFFECTS
ALKYLATING AGENTS
COMPARATIVE EVALUATIONS
DNA REPLICATION
ESCHERICHIA COLI
METABOLISM
MUTATIONS
ULTRAVIOLET RADIATION
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
ELECTROMAGNETIC RADIATION
MICROORGANISMS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATIONS
RECOVERY
REPAIR
550400* - Genetics
550700 - Microbiology