The effect of hyperthyroidism on opiate receptor binding and pain sensitivity

Journal Article · Sun Dec 31 23:00:00 EST 1989 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90160-S· OSTI ID:6098506

Edmondson, E A ^[1]; Bonnet, K A; Friedhoff, A J ^[2]

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1. Baylor College of Medicine, Houston, TX (USA)
2. New York Univ. School of Medicine, NY (USA)

This study was conducted to determine the effect of thyroid hormone on opiate receptor ligand-binding and pain sensitivity. Specific opiate receptor-binding was performed on brain homogenates of Swiss-Webster mice. There was a significant increase in {sup 3}H-naloxone-binding in thyroxine-fed subjects (hyperthyroid). Scatchard analysis revealed that the number of opiate receptors was increased in hyperthyroid mice (Bmax = 0.238 nM for hyperthyroid samples vs. 0.174 nM for controls). Binding affinity was unaffected (Kd = 1.54 nM for hyperthyroid and 1.58 nM for control samples). When mice were subjected to hotplate stimulation, the hyperthyroid mice were noted to be more sensitive as judged by pain aversion response latencies which were half that of control animals. After morphine administration, the hyperthyroid animals demonstrated a shorter duration of analgesia. These findings demonstrate that thyroxine increases opiate receptor number and native pain sensitivity but decreases the duration of analgesia from morphine.

• OSTI ID: 6098506
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 47:24; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DISEASES
DRUGS
ENDOCRINE DISEASES
ENDORPHINS
HORMONES
HYDROGEN COMPOUNDS
HYPERTHYROIDISM
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MEMBRANE PROTEINS
MICE
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PAIN
PEPTIDE HORMONES
PROTEINS
REACTION KINETICS
RECEPTORS
RODENTS
SYMPTOMS
THYROID HORMONES
THYROXINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES