Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Study of gastrointestinal opiate receptors: the role of the mu receptor on gastric emptying: concise communication

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5687210
;

Animal and in vitro experiments suggest that opiates exert their actions by interaction with possibly five different subtypes of opiate receptors, identified as mu, kappa, sigma, delta, and epsilon. As yet there is no conclusive evidence for their existence in man. Our experiments on morphine and the enkephalin analog DAMME have suggested at least two types of opiate receptors involved in gastric secretion. In this study we have used the very powerful and nonselective opiate agonist etorphine to stimulate as many of the different opiate receptors as possible. We have then attempted to block selectively the ..mu.. receptor by administering a small dose of naloxone. Etorphine delayed gastric emptying whereas naloxone alone had no effect. In combination, the inhibitory effect of etorphine on gastric emptying was incompletely prevented while the subjective effects of etorphoine were completely abolished. These results may indicate that ..mu.. receptors are important in the regulation of gastric emptying, but that other (non-..mu..) receptors are also involved. The radionuclide study of gastric emptying, as used here, is a potentially powerful tool in physiological research on the gastrointestinal tract.

Research Organization:
Univ. of Western Ontario, London
OSTI ID:
5687210
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:8; ISSN JNMEA
Country of Publication:
United States
Language:
English

Similar Records

Characterization of opiate receptor heterogeneity using affinity ligands and phospholipase A/sub 2/
Thesis/Dissertation · Mon Dec 31 23:00:00 EST 1984 · OSTI ID:5006490
Effect of thyrotrophin releasing hormone on opiate receptors of the rat brain
Journal Article · Wed Dec 31 23:00:00 EST 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States) · OSTI ID:6478059
Alteration of dopamine receptor sensitivity by opiates and the subsequent effect of this alteration on opiate tolerance and dependence
Thesis/Dissertation · Mon Dec 31 23:00:00 EST 1984 · OSTI ID:6062280

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
NARCOTICS
NUCLEI
ODD-EVEN NUCLEI
PHYSIOLOGY
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RECEPTORS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES