Effect of thyrotrophin releasing hormone on opiate receptors of the rat brain
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6478059
It has recently been shown that the hypothalamic thyrotropin releasing hormone (TRH) has the properties of a morphine antagonist, blocking its inhibitory action on respiration and, to a lesser degree, its analgesic action. This suggests that the antagonistic effects of TRH are mediated through its interaction with opiate receptors. The aim of this paper is to study this hypothesis experimentally. Tritium-labelled enkephalins in conjunction with scintillation spectroscopy were used to assess the receptor binding behavior. The results indicate the existence of interconnections between the opiate systems and TRH. Although it is too early to reach definite conclusions on the mechanisms of this mutual influence and its physiological significance it can be tentatively suggested that TRH abolishes the pharmacological effects of morphine by modulating the functional state of opiate reception.
- Research Organization:
- V.P. Serbskii All-Union Research Institute of General and Forensic Psychiatry, Moscow, USSR
- OSTI ID:
- 6478059
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 102:8; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:6324786
Related Subjects
550201 -- Biochemistry-- Tracer Techniques
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALOIDS
ANALGESICS
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COUNTING TECHNIQUES
DRUGS
ENDORPHINS
ENKEPHALINS
HORMONES
INHIBITION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEMBRANE PROTEINS
MORPHINE
NARCOTICS
NERVE CELLS
NERVOUS SYSTEM
NEUROREGULATORS
OPIUM
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIORECEPTOR ASSAY
RATS
RECEPTORS
RESPIRATION
RESPONSE MODIFYING FACTORS
RODENTS
SCINTILLATION COUNTING
SOMATIC CELLS
TRACER TECHNIQUES
TRH
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALOIDS
ANALGESICS
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COUNTING TECHNIQUES
DRUGS
ENDORPHINS
ENKEPHALINS
HORMONES
INHIBITION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEMBRANE PROTEINS
MORPHINE
NARCOTICS
NERVE CELLS
NERVOUS SYSTEM
NEUROREGULATORS
OPIUM
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIORECEPTOR ASSAY
RATS
RECEPTORS
RESPIRATION
RESPONSE MODIFYING FACTORS
RODENTS
SCINTILLATION COUNTING
SOMATIC CELLS
TRACER TECHNIQUES
TRH
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES