Interaction of ethanol with opiate receptors
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6999704
The authors study the action of ethanol on membrane-bound opiate receptors. Ethanol at 37/sup 0/C was shown to produce dose-dependent inhibition of binding of /sup 3/H-naloxone with opiate receptors. ID/sub 50/ under these conditions was 462 mM. Temperature-dependent inhibition of ligand-receptor binding suggests that ethanol does not compete for the stereospecific binding site of /sup 3/H-naloxone. Analysis of the inhibitory action of ethanol on /sup 3/H-naloxone binding in animals at different stages of experimental alcoholism revealed no differences between the control and experimental animals after 3.5 and 10 months of voluntary alcoholization.
- Research Organization:
- Res. Institute of Pharmacology Acad. of Medical Sci
- OSTI ID:
- 6999704
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:11; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHRONIC EXPOSURE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ETHANOL
HYDROXY COMPOUNDS
INHIBITION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NARCOTICS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIORECEPTOR ASSAY
RATS
REACTION KINETICS
RECEPTORS
RETENTION
RODENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHRONIC EXPOSURE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ETHANOL
HYDROXY COMPOUNDS
INHIBITION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NARCOTICS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIORECEPTOR ASSAY
RATS
REACTION KINETICS
RECEPTORS
RETENTION
RODENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES