Tissue enzyme changes in parabiotic rats with subcutaneous lymphoma or fibrosarcoma

Journal Article · Sat Apr 01 04:00:00 EST 1978 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6098345

Herzfeld, A; Greengard, O; Warren, S

A solid lymphoma implanted into normal inbred Kx rats and one partner of parabiotic pairs caused appareciable decreases in hepatic ornithine aminotransferase and arginase about a week earlier (4 to 6 days after implantation) in single hosts than in parabiotic hosts. By 18 to 21 days significant decreases in both enzymes were apparent in the host partner also. The hepatic thymidine kinase showed a five-fold elevation in single hosts 4 days after implantation; by 14 days its levels were about 200 times above normal and had also risen in the parabiotic hosts (20-fold) and host partners (four-fold). Implantation of fibrosarcoma caused qualitatively similar but generally less pronounced changes in these three enzymes in livers of single hosts, parabiotic hosts, and host partners. The splenic thymidine kinase 14 days after implantation was increased from control levels of about 3 U/g to 50.6, 44.8, and 13.5 U/g in single hosts, parabiotic hosts, and host partners, respectively. At later stages, 17 to 20 days after implantation of the lymphoma, appreciable amounts of thymidine kinase appeared in the plasma: The units of activity per milliliter were 6.2 in single hosts, 0.79 in parabiotic hosts, and 0.55 in host partners (control < 0.05). Observations on the changes in hepatic and splenic enzymes in parabiotic rats suggest that effects of neoplasms on distant host tissues are mediated by humoral factors. The less pronounced responses in parabiotic than in single hosts indicate that the tumor-free partner affords some protection against these systemic effects.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 6098345
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 60:4; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
AMINOTRANSFERASES
ANIMALS
ARGINASE
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISEASES
ENZYME ACTIVITY
ENZYMES
FIBROSARCOMAS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROLASES
LIVER
LYMPHOMAS
MAMMALS
MOSAICISM
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
ORNITHINE
PARABIOSIS
PHOSPHOTRANSFERASES
PYRIMIDINES
RATS
RIBOSIDES
RODENTS
SARCOMAS
SPLEEN
THYMIDINE
TISSUES
TRANSFERASES
VERTEBRATES