Correlation of local cerebral blood flow, glucose utilization, and tissue pH following a middle cerebral artery occlusion in the rat
Journal Article
·
· Stroke; (United States)
The use of three sets of the double-tracer autoradiographic technique to measure topographical changes of local cerebral blood flow (LCBF), glucose utilization (LCGU), and tissue pH following a 3 h middle cerebral artery (MCA) occlusion in the rat is described. In a sham-operated group of animals there was 10% reduction of LCBF and 7% reduction of LCGU in the most affected areas as compared to the contralateral homologous regions. However, the ratio of LCGU/LCBF in the affected areas remained within normal limits. In the MCA-occluded animals, LCGU showed a bimodal response to decreased LCBF. LCGU decreased with reduced LCBF until LCBF fell to 38% of normal. Below this LCBF level LCGU increased, most likely implying anerobic glycolysis. Decline of tissue pH corresponds to the mismatch of LCBF and LCGU. These results suggest that brain tissue pH change cannot be predicted on the basis of LCBF or LCGU alone.
- Research Organization:
- McGill Univ., Quebec, Canada
- OSTI ID:
- 6084565
- Journal Information:
- Stroke; (United States), Journal Name: Stroke; (United States) Vol. 5; ISSN SJCCA
- Country of Publication:
- United States
- Language:
- English
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· Stroke; (United States)
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
ANTIPYRETICS
ANTIPYRINE
AUTORADIOGRAPHY
AZOLES
BLOOD FLOW
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIAGNOSIS
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
ELEMENTS
FLUORINE
GLUCOSE
HALOGENS
HETEROCYCLIC COMPOUNDS
HEXOSES
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PH VALUE
PYRAZOLES
PYRAZOLINES
RATS
RODENTS
SACCHARIDES
VASCULAR DISEASES
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
ANTIPYRETICS
ANTIPYRINE
AUTORADIOGRAPHY
AZOLES
BLOOD FLOW
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIAGNOSIS
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
ELEMENTS
FLUORINE
GLUCOSE
HALOGENS
HETEROCYCLIC COMPOUNDS
HEXOSES
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PH VALUE
PYRAZOLES
PYRAZOLINES
RATS
RODENTS
SACCHARIDES
VASCULAR DISEASES
VERTEBRATES