Development of animal models for evaluation of technetium-99m renal tubular function agents

Thesis/Dissertation · Tue Jan 01 04:00:00 EST 1985

OSTI ID:6082400

Eshima, D

Diamide dimercaptide (N/sub 2/,S/sub 2/) and triamide mercaptide (N/sub 3/S) complexes of technetium-99m were shown to have potential use as a new class of renal tubular function agents. The biological evaluation of a number of these new Tc-99m chelating agents was performed in order to develop an optimal animal strategy for the screening of these agents as well as other potential complexes. Various animal models were studied to determine the potential correlation of the rate of renal clearance and specificity for the renal transport system between the various animal species and humans. There was no single animal species which could routinely predict the performance of the complexes in humans. Therefore, the use of a select number of performance parameters, which were obtained from studies in the mouse, rat or dog were utilized to develop a set of criteria to predict the performance in humans. The use of these animal models minimized extrapolation errors, if limitations were placed on the amount of information which would be utilized from each of them. There were a number of complexes which appeared promising when evaluated in view of these species limitations. The evaluation of Tc-99m-mercaptoacetylglycylglycylglycine (Tc-99m-MAG/sub 3/) was found to perform well in all of the various animal models. Tc-99m-MAG/sub 3/ was therefore utilized to develop an understanding for its pathway of elimination. The results from these studies show that Tc-99m-MAG/sub 3/ is cleared from the body by the kidney primarily by renal tubular secretion processes.

• Research Organization: Utah Univ., Salt Lake City (USA)
• OSTI ID: 6082400
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BODY
CHELATING AGENTS
CLEARANCE
COMPLEXES
DIAGNOSTIC USES
DOGS
DRUGS
EVALUATION
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
MAMMALS
MAN
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PERFORMANCE
PRIMATES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RENAL CLEARANCE
RODENTS
SULFUR COMPOUNDS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES