Animal evaluation of technetium-99m triamide mercaptide complexes as potential renal imaging agents

Journal Article · Wed Jul 01 00:00:00 EDT 1987 · J. Nucl. Med.; (United States)

OSTI ID:6276235

Eshima, D; Taylor, A Jr; Fritzberg, A R; Kasina, S; Hansen, L; Sorenson, J F

Technetium-99m mercaptoacetylglycylglycylglycine (MAG3), a (/sup 99m/Tc)triamide mercaptide (N3S) compound has been synthesized in an attempt to obviate the stereochemistry problems associated with the diamide dimercaptide (N2S2) ligands. Because initial studies have been promising, the terminal glycine on the MAG3 compound has been varied to create a new series of N3S compounds. Twelve new N3S complexes were initially screened in mice and the more promising complexes, /sup 99m/Tc mercaptoacetylgylcylglycyl-glycine ((/sup 99m/Tc)MAG3), /sup 99m/Tc mercaptoacetylgylcylglycyl-L-alanine ((/sup 99m/Tc)MAG2-Ala), and both complexes of /sup 99m/Tc mercaptoeacetylglycylglycyl-L-asparagine ((/sup 99m/Tc)MAG2-Asn) and /sup 99m/Tc mercaptoacetylglycylglycyl-L-glutamine ((/sup 99m/Tc)MAG2-Gln), were further evaluated in rats utilizing constant infusion blood clearances, extraction efficiencies and protein binding assays. The renal excretion of all these complexes compared favorably with simultaneously administered (/sup 131/I)OIH and (/sup 125/I)iothalamate. The triamide mercaptide complexes represent a new ligand class for /sup 99m/Tc, which may provide a variety of complexes for the evaluation of renal tubular function.

• Research Organization: Univ. of Utah, Salt Lake City
• OSTI ID: 6276235
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 28:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
COMPLEXES
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIGANDS
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RENAL CLEARANCE
RODENTS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES