Chemistry and biology of Tc-99m renal function agents. Final report
Technical Report
·
OSTI ID:5562263
A major aim of the project was to develop a Tc-99m renal tubular function radiopharmaceutical. Progress was made in synthesizing and evaluating Tc-99m 2,3-dimercaptoaceta-midoprepanoate (CO/sub 2/DADS). In animals and clinical studies the A epimer (early component on reversed phase HPLC) demonstrated high efficiency and specificity for renal tubular secretion. We were unable to obtain only the desired stereoisomer. Synthesis of about twenty diamide dimercaptide N/sub 2/S/sub 2/ ligand analogs suggested two others that were of comparable efficiency in humans, but with less difference between stereoisomers; Tc-99m 1,3-dimercaptoacetamide-2-hydroxypropane (HoDADS) and 1,8-dithiol- 2,7-dioxo-3,6-diazanonanoate (..cap alpha.. -S-CO/sub 2/DADS). 15 refs.
- Research Organization:
- Washington Univ., Seattle (USA). Dept. of Medicinal Chemistry
- DOE Contract Number:
- FG06-85ER60343
- OSTI ID:
- 5562263
- Report Number(s):
- DOE/ER/60343-1; ON: DE86012057
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Chemistry and biology of Tc-99m renal function radiopharmaceuticals. Final report, May 1, 1982-January 15, 1983
Journal Article
·
Wed Oct 01 00:00:00 EDT 1986
· J. Med. Chem.; (United States)
·
OSTI ID:7024070
Triamide mercaptide (N/sub 3/S) ligands for Tc-99m as potential Tc-99m renal function agents
Conference
·
Wed May 01 00:00:00 EDT 1985
· J. Nucl. Med.; (United States)
·
OSTI ID:6795742
Chemistry and biology of Tc-99m renal function radiopharmaceuticals. Final report, May 1, 1982-January 15, 1983
Technical Report
·
Fri Dec 31 23:00:00 EST 1982
·
OSTI ID:6191607
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHEMICAL PREPARATION
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHEMICAL PREPARATION
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES