Elucidation of the mechanism of vitamin A potentiation of carbon tetrachloride-induced liver injury
Thesis/Dissertation
·
OSTI ID:6070620
Male SD rats were given Vitamin A daily for 7 days by oral gavage. 24 hr after the last dose of Vitamin A, they were then challenged with CCl/sub 4/. Ethane, as a marker of lipid peroxidation, was measured during the first 2 hr and hepatic injury was assessed at 24 hr after CCl/sub 4/. There was approximately 5-fold increase in ethane exhalation and 17-fold increase in Plasma GPT activity in Vitamin A/CCl/sub 4/ group. There was also increase in the incidence of hepatocellular necrosis. Vitamin A pretreatment did not increase the metabolism of /sup 14/CCl/sub 4/ as examined by the amount of exhaled /sup 14/CO/sub 2/, and the covalent binding of /sup 14/C-equivalents to liver lipids and proteins. In addition, liver levels of Vitamin E or GSH were not changed by Vitamin A. Electron microscopic analysis of livers from Vitamin A treated rats revealed activated Kupffer cells. To determine if the Kupffer cells were functionally more active, the clearance of intravenously administered colloidal carbon from the blood of Vitamin A treated rats was compared to that of control rats.
- Research Organization:
- Arizona Univ., Tucson (USA)
- OSTI ID:
- 6070620
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MARKERS
BLOOD-PLASMA CLEARANCE
BODY
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARBON TETRACHLORIDE
CHALCOGENIDES
CHLORINATED ALIPHATIC HYDROCARBONS
CLEARANCE
DIGESTIVE SYSTEM
ENZYME ACTIVITY
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
KINETICS
LIPIDS
LIVER
MAMMALS
METABOLISM
NECROSIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RATS
REACTION KINETICS
RODENTS
VERTEBRATES
VITAMIN A
VITAMINS
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MARKERS
BLOOD-PLASMA CLEARANCE
BODY
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARBON TETRACHLORIDE
CHALCOGENIDES
CHLORINATED ALIPHATIC HYDROCARBONS
CLEARANCE
DIGESTIVE SYSTEM
ENZYME ACTIVITY
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
KINETICS
LIPIDS
LIVER
MAMMALS
METABOLISM
NECROSIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RATS
REACTION KINETICS
RODENTS
VERTEBRATES
VITAMIN A
VITAMINS