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Effects of ethanol and carbon tetrachloride upon vitamin A status of rats

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:6933157
; ;
The effects of ethanol (ET) and carbon tetrachloride (CCL/sub 4/) upon tissue vitamin A, liver lipids, liver cytochrome P/sub 450/ and hepatic morphology were investigated. After a two week feeding period, young male rats were divided into four groups. For 5 weeks one group of rats (n=18) received ET in liquid diets (30% of calories) while another (n=8) was exposed to CCL/sub 4/ inhalation twice a week along with phenobarbitol in the diet. All groups received the NRC recommended level for vitamin A. Comparison of ET and its pair-fed control group revealed; decreased hepatic vitamin A, no change in serum vitamin A, increased % liver lipid and cytochrome P/sub 450/ with minimal fat accumulation in hepatocytes. Comparison of CCL/sub 4/ group with pair-fed controls showed; increased serum vitamin A, decreased hepatic vitamin A, increased cytochrome P/sub 450/, marked hepatic fat accumulation, hepatic cell necrosis and early cirrhosis. Thus, CCL/sub 4/, which is a more potent hepatotoxin as evidenced by a more elevated cytochrome P/sub 450/ and distorted liver morphology, not only reduced liver vitamin A, but also increased serum vitamin A. The hepatic response to CCL/sub 4/ may mimic a more cirrhotic condition such as that resulting from longer-termed ET intake.
Research Organization:
Univ. of Illinois, Urbana
OSTI ID:
6933157
Report Number(s):
CONF-8604222-
Conference Information:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:6
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMAL CELLS
ANIMALS
CARBON TETRACHLORIDE
CHLORINATED ALIPHATIC HYDROCARBONS
ETHANOL
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROXY COMPOUNDS
LIPIDS
LIVER CELLS
MAMMALS
METABOLISM
NECROSIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOLOGICAL CHANGES
RATS
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES
VITAMIN A
VITAMINS