Effects of ethanol and carbon tetrachloride upon vitamin A status of rats
The effects of ethanol (ET) and carbon tetrachloride (CCL/sub 4/) upon tissue vitamin A, liver lipids, liver cytochrome P/sub 450/ and hepatic morphology were investigated. After a two week feeding period, young male rats were divided into four groups. For 5 weeks one group of rats (n=18) received ET in liquid diets (30% of calories) while another (n=8) was exposed to CCL/sub 4/ inhalation twice a week along with phenobarbitol in the diet. All groups received the NRC recommended level for vitamin A. Comparison of ET and its pair-fed control group revealed; decreased hepatic vitamin A, no change in serum vitamin A, increased % liver lipid and cytochrome P/sub 450/ with minimal fat accumulation in hepatocytes. Comparison of CCL/sub 4/ group with pair-fed controls showed; increased serum vitamin A, decreased hepatic vitamin A, increased cytochrome P/sub 450/, marked hepatic fat accumulation, hepatic cell necrosis and early cirrhosis. Thus, CCL/sub 4/, which is a more potent hepatotoxin as evidenced by a more elevated cytochrome P/sub 450/ and distorted liver morphology, not only reduced liver vitamin A, but also increased serum vitamin A. The hepatic response to CCL/sub 4/ may mimic a more cirrhotic condition such as that resulting from longer-termed ET intake.
- Research Organization:
- Univ. of Illinois, Urbana
- OSTI ID:
- 6933157
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:6; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARBON TETRACHLORIDE
TOXICITY
ETHANOL
LIVER CELLS
NECROSIS
VITAMIN A
METABOLISM
LIPIDS
RATS
ALCOHOLS
ANIMAL CELLS
ANIMALS
CHLORINATED ALIPHATIC HYDROCARBONS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROXY COMPOUNDS
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOLOGICAL CHANGES
RODENTS
SOMATIC CELLS
VERTEBRATES
VITAMINS
560300* - Chemicals Metabolism & Toxicology