Dose-responsive model of smoke inhalation injury. Severity-related alteration in cardiopulmonary function
The dose responsiveness of selected physiologic indices was studied in a sheep model of smoke inhalation injury. In this model, graded severity of injury was achieved by changing the contact time with smoke (defined by unit), whereas other variables were kept constant. Blood gas and cardiopulmonary indices were measured in 70 sheep, including 12 controls, either 24 or 72 hours after exposure to 3, 6, 9, 12, 15, or 18 units of smoke. A 12-unit dose of smoke was fatal within 72 hours and an 18-unit dose was fatal within 24 hours. The best correlation between smoke dose and response was observed in arterial oxygen tension 24 hours after exposure. At 24 hours, most of the cardiopulmonary indices showed significant change only after a 12-unit exposure. Although the exact shape of the dose-response curve could not be defined, sigmoid or curved linear shape was suggested, reflecting the progressive deterioration.
- Research Organization:
- Army Institute of Surgical Research, San Antonio, TX
- OSTI ID:
- 6068818
- Journal Information:
- Ann. Surg.; (United States), Journal Name: Ann. Surg.; (United States) Vol. 206:1; ISSN ANSUA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MODELS
BODY
COLLOIDS
DISPERSIONS
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EPITHELIUM
INHALATION
INTAKE
MAMMALS
NONMETALS
OXYGEN
RESIDUES
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
SMOKES
SOLS
TISSUES
TOXICITY
TRACHEA
VERTEBRATES