Smoke-inhalation injury and the effect of carbon monoxide in the sheep model
The role of carbon monoxide (CO) in causing the physiologic and anatomic changes characteristic of smoke inhalation injury was evaluated in 34 sheep. The smoke-exposed group received a dose of smoke known to produce mild inhalation injury. The CO group received a pure gas mixture that contained concentrations of oxygen, carbon dioxide, and CO similar to those in the smoke. Cardiopulmonary function was measured immediately after exposure, and 24 and 72 hours after exposure. The CO group showed a transient increase in cardiac output, but the smoke group showed no such response. The CO group maintained normal PaO2 levels during the 72-hour study period; the smoke group gradually developed hypoxemia. The lungs of the CO exposed animals had no discernible histologic changes. These results indicate that CO per se is not the primary etiologic agent of smoke inhalation injury.
- Research Organization:
- Army Inst. of Surgical Research, Fort Sam Houston, TX (USA)
- OSTI ID:
- 5978995
- Report Number(s):
- AD-A-228858/7/XAB
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
DISPERSIONS
DOMESTIC ANIMALS
DYNAMIC FUNCTION STUDIES
HEART
INHALATION
INTAKE
LUNGS
MAMMALS
MIXTURES
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RUMINANTS
SENSITIVITY
SHEEP
TOXICITY
VERTEBRATES