Hemodynamic effects of stable strontium in dogs
Conference
·
· Trace Subst. Environ. Health; (United States)
OSTI ID:6064468
The current study was undertaken to ascertain the effect of prolonged IV infusion of Sr/sup 2 +/ on Sr:Ca ratios, as well as on hemodynamic changes. Sr gluconate was infused IV at constant rate of 0.7 ml/min. to 9 adult dogs, anesthetized with Nembutal for periods of 300 min. 3 dogs were infused with normal saline for the same periods. Samples for Sr/sup 2 +/ and Ca/sup 2 +/ and hemodynamic data were taken at q 30 min. The normal Sr:Ca ratio in dogs (1:507) was found to be much higher than in humans (1:2000). Sr/sup 2 +/ infusion resulted in a gradual increase of Sr/sup 2 +/ without significant change in serum Ca/sup 2 +/; fluctuations in Ca/sup 2 +/ conc. returned to normal values in the 2 mg/ml group. In the 8 mg/ml group, some decrease in serum Ca/sup 2 +/ was observed. Serum Sr/sup 2 +/ conc. increased X 163 (+/- 80) in the 2 mg Sr/ml group; x 727 (+/- 204) in the 8 mg Sr/ml group. Hemodynamic studies included measurements of Pa, Pw, CO, P syst, HR, PVR and SVR. No significant hemodynamic changes were observed following 2 mg/ml Sr/sup 2 +/ infusion. In the 8 mg/ml group, HR and CO were decreased while PVR and SVR were significantly increased. 11 references, 8 figures.
- Research Organization:
- McGill Univ., Montreal, Quebec
- OSTI ID:
- 6064468
- Report Number(s):
- CONF-860626-
- Conference Information:
- Journal Name: Trace Subst. Environ. Health; (United States)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BIOLOGICAL EFFECTS
CALCIUM COMPOUNDS
DATA
DISTRIBUTION
DOGS
EXPERIMENTAL DATA
INFORMATION
MAMMALS
METABOLISM
NUMERICAL DATA
QUANTITY RATIO
STRONTIUM COMPOUNDS
TISSUE DISTRIBUTION
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BIOLOGICAL EFFECTS
CALCIUM COMPOUNDS
DATA
DISTRIBUTION
DOGS
EXPERIMENTAL DATA
INFORMATION
MAMMALS
METABOLISM
NUMERICAL DATA
QUANTITY RATIO
STRONTIUM COMPOUNDS
TISSUE DISTRIBUTION
VERTEBRATES