THE RENAL EXCRETION OF STRONTIUM AND CALCIUM IN DOGS
Renal excretion and plasma clearance rates of Sr/sup 85/ and Ca/sup 45/ were determined in trained female dogs 18 to 24 hours after the simultaneous intravenous or subcutaneous administration of these two isotopes. Tubular reabsorption of Ca/sup 45/ in the normal dog was nearly complete, beimg more than 99% of that filtered at the glomeruli. The reabsorption of Sr/sup 85/ was consistently less than that of calcium, averaging less than 98%. Clearance measurements, using endogenous creatinine for determining the glomerular filtration rate, indicated a more rapid clearance from the plasma of the strontium isotope (0.91 ml/min for Sr/sup 85/ and 0.17 ml/min for Ca/sup 45/). As a result of these differences, the excretion of Sr/sup 45/ was 5 to 6 times more rapid than that of Ca/sup 45/. Drastic changes in plasma-calcium levels, as achieved by thyropara-thyroidectomy and parathyroid-, extract injection, did not appreciably alter the ratio of he excretion rates despite marked changes in the absolute values. The infusion of sodium citrate caused large increases in the urinary excretion of both strontium and calcium and countered the renal discrimination process. The excretion of both ions was also significantly increased during alkalosis brought about by the infusion of sodium bicarbonate. Acidosis was without effect. (auth)
- Research Organization:
- Univ. of Rochester, N.Y.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-001447
- OSTI ID:
- 4835376
- Journal Information:
- Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 3
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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