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Transformation of Haemophilus influenzae by recombinant molecules

Conference ·
OSTI ID:6061787
A gene library of Haemophilus influenzae DNA has been constructed by ligating chromosomal DNA from cells resistant to a number of antibiotics, together with DNA of the H. influenzae plasmid RSF0885. Before ligation both DNAs were cut with the enzyme PvuII. The ligated DNA was allowed to enter competent H. influenzae sensitive to the antibiotics and selection was made for resistance to ampicillin, conferred by the plasmid RSF0885 DNA. Plasmids conferring resistance to various other antibiotics, as well as to ampicillin, have been obtained by this procedure and subsequent selection for chromosomal markers.
Research Organization:
Brookhaven National Lab., Upton, NY (USA)
DOE Contract Number:
AC02-76CH00016
OSTI ID:
6061787
Report Number(s):
BNL-29733; CONF-8106127-1; ON: DE81032039
Country of Publication:
United States
Language:
English

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