Effects of chemical carcinogens of hemopoiesis, immunopoiesis and viral oncogenesis. Technical progress report, December 1, 1977--September 30, 1978. [Mechanisms of potentiation of viral leukemogenesis by MMS, benzopyrene, and DMBA]

Technical Report · Sun Oct 01 04:00:00 EDT 1978

DOI:https://doi.org/10.2172/6060900· OSTI ID:6060900

OKunewick, J P; Raikow, R B; Meredith, R F

During the past year we have concentrated on defining the circumstances under which methyl methanesulfonate (MMS), benzo(a) pyrene (BP), and 7,12-dimethylbenz(a)anthracene (DMBA) interact with Friend virus (FLV) to produce leukemia. The optimum scheduling for each and also the effective dose levels of the chemicals have been partially determined. There are at least three critical factors which govern whether or not a leukemogenic interaction can be shown between the chemical agents and the virus. These are chemical dose, virus dose, and their relative time of administration. The most critical of these is virus dose. The optimum virus dose is that which results in between 25 and 40% incidence of leukemia within 40 days after virus infection when virus is given alone. The chemical carcinogens have a lower dose threshold, below which no significant potentiating effect can be observed. The only upper limit would appear to be acute drug toxicity. The third element, timing, is equally critical and varies according to the chemical. This variation may reflect different mechanisms of action by the chemical agents and/or different pharmacology. Data on the effects of MMS, BP, and DMBA on the immune system have indicated that the viral enhancement is probably not dependent on this function. Further enhancement of the potentiation of viral leukemogenesis was observed using benzo(a)pyrene and caffeine, indicating that the inhibition by caffeine of DNA repair may be an important factor in virus potentiation. (ERB)

• Research Organization: Allegheny General Hospital, Pittsburgh, PA (USA). Cancer Research Unit
• OSTI ID: 6060900
• Report Number(s): COO-4800-4
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CAFFEINE
CARCINOGENESIS
CARCINOGENS
CONDENSED AROMATICS
DATA
DATA FORMS
DISEASES
DNA
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ESTERS
ETIOLOGY
EXPERIMENTAL DATA
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
IMMUNE REACTIONS
INFORMATION
INHIBITION
ISOLATED VALUES
LEUKEMIA
LEUKEMIA VIRUS
LEUKEMOGENESIS
MAMMALS
METHYL METHANESULFONATE
MICE
MUTAGENS
NEOPLASMS
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PATHOGENESIS
PURINES
RECOVERY
REPAIR
RODENTS
STRAND BREAKS
SULFONIC ACID ESTERS
SYNERGISM
TIME DEPENDENCE
VERTEBRATES
XANTHINES