Gene mutation, quantitative mutagenesis, and mutagen screening in mammalian cells: study with the CHO/HGPRT system
Conference
·
OSTI ID:6060657
We have employed CHO cells to develop and define a set of stringent conditions for studying mutation induction to TG resistance. Several lines of evidence support the CHO/HGPRT system as a specific-locus mutational assay. The system permits quantification of mutation at the HGPRT locus induced by various physical and chemical mutagens. The quantitative nature of the system provides a basis for the study of structure-function relationships of various classes of chemical mutagens. The intra- and interlaboratory reproducibility of this system suggests its potential for screening environmental agents for mutagenic activity.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6060657
- Report Number(s):
- CONF-8010221-1; ON: DE82001496
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550400 -- Genetics
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
ELECTROMAGNETIC RADIATION
GENE MUTATIONS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HAMSTERS
MAMMALS
MUTAGEN SCREENING
MUTAGENESIS
MUTAGENS
MUTATIONS
PERFORMANCE TESTING
RADIATION EFFECTS
RADIATIONS
RODENTS
SCREENING
TESTING
ULTRAVIOLET RADIATION
VERTEBRATES
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
ELECTROMAGNETIC RADIATION
GENE MUTATIONS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HAMSTERS
MAMMALS
MUTAGEN SCREENING
MUTAGENESIS
MUTAGENS
MUTATIONS
PERFORMANCE TESTING
RADIATION EFFECTS
RADIATIONS
RODENTS
SCREENING
TESTING
ULTRAVIOLET RADIATION
VERTEBRATES