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Specific in vivo binding of /sup 77/Br-brombenperidol in rat brain

Journal Article · · Life Sci.; (United States)
;
The in vivo binding of the radiobrominated neuroleptic brombenperidol in rat brain was studied. The accumulation of the radiolabeled neuroleptic was high in the striatum and relatively low in the cerebellum, cortex, and blood. Striatal binding of brombenperidol was saturable and displaced by subsequent administration of benperidol. The rationale for the development of /sup 75/Br-brombenperidol as a radiopharmaceutical for the non-invasive imaging of cerebral dopamine receptor areas is presented.
Research Organization:
Kernforschungsanlage, Juelich, West Germany
OSTI ID:
6052514
Journal Information:
Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 35:13; ISSN LIFSA
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BODY
BRAIN
BROMINE 77
BROMINE ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL BONDS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOPAMINE
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HYDROXY COMPOUNDS
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PSYCHOTROPIC DRUGS
RADIOASSAY
RADIOISOTOPES
RATS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANQUILIZERS
VERTEBRATES