Specific in vivo binding of /sup 77/Br-p-bromospiroperidol in rat brain: a potential tool for gamma ray imaging

Journal Article · Mon Apr 27 04:00:00 EDT 1981 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(81)90298-8· OSTI ID:6621627

Kulmala, H K ^[1]; Huang, C C; Dinerstein, R J; Friedman, A M

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1. Univ. of Chicago, IL

The binding of the gamma labeled neuroleptic, /sup 77/Br-p-bromospiroperidol, in the rat brain was examined in vivo. This binding parallels the binding of /sup 3/H-spiroperidol, in that binding is especially high in dopaminergically innervated areas, is saturable, and is displaced by high doses of unlabeled spiroperidol. Thus, /sup 77/Br-p-bromospiroperidol is a suitable ligand for use in gamma ray imaging techniques for in vivo monitoring of receptor binding.

• OSTI ID: 6621627
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 28:17; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BODY
BRAIN
BROMINE 77
BROMINE ISOTOPES
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FEASIBILITY STUDIES
INTERMEDIATE MASS NUCLEI
ISOTOPES
KETONES
LABELLED COMPOUNDS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RECEPTORS
RODENTS
SCINTISCANNING
VERTEBRATES