Radioiodinated 2'-iodospiperone: a new radioligand for in vivo dopamine receptor study

Journal Article · Mon Oct 26 04:00:00 EST 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(87)90473-5· OSTI ID:6076126

Saji, H; Nakatsuka, I; Shiba, K; Tokui, T; Horiuchi, K; Yoshitake, A; Torizuka, K; Yokoyama, A

In vivo dopamine receptor binding of the newly synthesized ligand, /sup 125/I-2'-iodospiperone (/sup 125/I-2'-ISP), was studied in mouse brain. The highest accumulation was found in the striatum. Analysis of the striatal homogenate showed the /sup 125/I-2'-ISP to be metabolically stable. Furthermore, this striatal binding was saturable and displaced only by dopaminergic drugs. On the other hand, the accumulation in the cortex was as low as that of the cerebellum and unaffected by the administration of serotoninergic drugs and dopaminergic drugs; results assessed by macroautoradiographic studies. Thus, the newly synthesized /sup 125/I-2'-ISP presented high affinity for dopamine receptors in vivo and therefore; holds great potential for the in vivo dopamine receptor studies, provided /sup 123/I becomes readily available. 17 references, 4 figures, 1 table.

• Research Organization: Kyoto Univ., Japan
• OSTI ID: 6076126
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 41:17; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AFFINITY
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DATA
DAYS LIVING RADIOISOTOPES
DOPAMINE
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
IN VIVO
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 125
IODINE ISOTOPES
ISOTOPES
KINETICS
LIGANDS
MAMMALS
MEMBRANE PROTEINS
MICE
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RECEPTORS
RODENTS
SPIPERONE
SYMPATHOMIMETICS
VERTEBRATES